Bruker AXS, BioSpin, Daltonics, and Optics, Limited

Bruker AXS has announced XRDWizard V2.9 support for Variable Counting Time (VCT), a data collection scheme for X-ray powder diffraction, where the measurement time is systematically increased towards higher 2theta angles. As a result, the natural steep intensity fall towards higher 2theta angles is compensated for, leading to dramatically improved data quality for all kinds of profile fitting applications. VCT data typically results
in: greatly enhanced chance for success in structure determination. Atomic coordinates, occupancy factors and (anisotropic) thermal parameters are better determined, especially in the case of light atoms. More stable refinement of atomic coordinates and thermal parameters of light atoms, including hydrogen. Substantially lower RWP
indicating a better overall fit.

The new TRACERturboSD from Bruker AXS claims to be the world’s first handheld X-ray Fluorescence (XRF) instrument that uses a Silicon Drift Detector (SDD) for dramatically
improved speed, sensitivity and resolution. Bruker’s industryleading proprietary XFlash SDD, previously available only in high-performance laboratory XRF instruments, now offers unprecedented speed and analytical specificity when integrated into the novel handheld TRACERturboSD. Now all handheld XRF customer segments can benefit from these performance advantages in their analytical work. In the general metals analysis markets the TRACERturboSD
offers higher speed, sensitivity and selectivity for many demanding handheld XRF applications.

Bruker AXS has announced that its SMART X2S automated chemical X-ray crystallography system has been awarded a R&D 100 award, recognising it as one of the 100 most technologically significant products introduced in the past year. The SMART X2S for the first time allows inorganic and organic chemists to produce atomic resolution, 3D molecular structures in their own laboratories quickly and easily at the touch of a button. The SMART X2S takes small molecule structure determination to the next level of convenience by automating the previously difficult aspects of X-ray structure
determination, from sample loading and alignment through data collection all the way to the mathematical structure solution, structure verification and report
generation.

Bruker Daltonics has announced the new further enhanced micrOTOF II API-TOF mass spectrometer, as well as a novel, optional GC-APCI Interface for a single high-performance platform for LC/MS and GC/MS with analyte flexibility. Bruker Daltonics has enhanced its well-known high-resolution API-TOF system, the micrOTOF, even further improving its resolution to greater than 16,500 and its mass accuracy to 1-2ppm. Even better mass accuracy plus SmartFormula makes the micrOTOF II an outstanding instrument in its class, providing the user with high confidence in formula determination and identification,
even in complex mixtures.

Bruker Daltonics has a number of new high performance mass spectrometry products and applications including: maXis, a high speed Ultra High Resolution TOF (UHR-TOF) mass spectrometer, offering a no-compromise solution for exceptional performance with accurate mass, ultra high resolution across a broad mass range; micrOTOF II is a new ESI-TOF system now
with enhanced mass spectrometry performance and a novel, optional LC and GC-APCI Interface expanding its capabilities; and MALDI-TDS, a novel application for Top-Down Sequencing (TDS) that typically delivers 100% protein sequence coverage,
C- and N- terminal assignments and provides unparalleled levels of information on protein
modifications of vital importance in fields such as recombinant protein production.

Several new Bruker solutions are available for cutting-edge small molecule analysis in the pharmaceutical and biotech industries, as well as in academic and clinical research: the new
Complete Molecular Confidence solution for small molecule analysis combines unambiguous on-the-fly SmartFormula3D molecular formula determination by our new ESI-Qq-TOF mass spectrometer with automated structure verification by NMR. Similarly exciting, drug and metabolite tissue imaging at therapeutic dosing levels is now enabled by a novel high-performance MALDI-FTMS imaging platform. Moreover, the new FlashFormula(TM) NALDI-TOF solution allows very rapid, highthroughput small molecule detection and identification without time-consuming LC separations.

Bruker Daltonics was the first company to introduce ETD (Electron Transfer Dissociation) on its commercial high-capacity trap. With the release of its new Compass 1.3 ion trap software, Bruker’s high-capacity trap HCTultra P Discovery System becomes the first commercial mass spectrometer fully equipped with both ETD and PTR (Proton Transfer Reaction). Using an ion optics design and chemistry setup for ETD/PTR allows rapid, routine top-down characterisation of large peptides and mid-size proteins in the high-capacity ion trap with superior sensitivity. The usefulness of ETD/PTR is demonstrated impressively by the unambiguous characterisation of post-translational modifications.

Bruker Daltonics has been awarded a $1.3 million followon Phase III contract for further research, development and
testing within the Autonomous Rapid Facility Chemical Agent Monitor (ARFCAM) program by the U.S. Department of Homeland Security (DHS). This Phase III program is expected to last about three years during which time Bruker will continue to improve its ARFCAM technology. ARFCAM Phase III is intended to lead to the next generation fully automated
and unattended chemical agent
and toxic chemicals detector for government facilities and critical infrastructure by the year 2011. Bruker Daltonics’ work in ARFCAM Phases I and II has already resulted in a commercial product line, called the RAID(TM)-AFM (Automated
Facilities Monitor).

Bruker Daltonics has said that it is taking orders worldwide for its new apex-ultra FTMS mass spectrometer which features
excellent dynamic range, ultra-high resolving power, and superb mass accuracy, plus faster data acquisition. Bruker’s unique refrigerated FTMS superconducting magnet technology
is available at 7, 9.4, 12 and now even 15 Tesla. It is the most powerful and flexible
FTMS system commercially available for
top- down proteomics and the analysis of
complex mixtures, e.g. in metabolomics or
petroleomics.

Bruker AXS has launched its compact and affordable SMART
X2S(TM) (Crystal-to-Structure), the first benchtop X-ray crystallography system for fully automated three-dimensional (3D)
chemical structure determination. It is designed for use by chemists who have no special training in crystallography and it is expected to appeal to many inorganic and organic chemists at colleges and universities, as well as in bio-pharma and chemical companies. The SMART X2S allows inorganic and organic chemists to produce atomic resolution, 3D structures of routine samples in their own laboratories quickly and easily at the touch of a button. The SMART X2S takes small molecule structure determination to the next level by automating the previously difficult aspects of X-ray structure determination, from sample loading and alignment through data collection all the way to the mathematical structure solution.

At the Denver X-ray Conference, Bruker AXS and Incoatec Germany, introduced a new Super Speed X-ray source-detector combination to further enhance current high-performance Bruker AXS instruments, including the popular Bruker D8 DISCOVER with GADDS and the Bruker NANOSTAR. The new Bruker Super Speed Solutions are powered with Incoatec’s Microfocus Source, the ImS, which is a sealed high brilliance micro focus tube in combination with a Quazar Montel multilayer optic for 2D beam shaping. The 30W source is low-weight and runs air-cooled, making it ideal for customer
applications and customer convenience.

At the Denver X-ray Conference, Bruker AXS and Incoatec Germany, introduced a new Super Speed X-ray source-detector combination to further enhance current high-performance Bruker AXS instruments, including the popular Bruker D8 DISCOVER with GADDS and the Bruker NANOSTAR. The new Bruker Super Speed Solutions are powered with Incoatec’s Microfocus Source, the ImS, which is a sealed high brilliance micro focus tube in combination with a Quazar Montel multilayer optic for 2D beam shaping. The 30W source is low-weight and runs air-cooled, making it ideal for customer
applications and customer convenience.